Explore the landscape

Move across real terrain.

This surface is estimated from national data, not drawn for illustration. Place the marker, follow the age path, and test a move.

Mortality hazard1.00× reference

eGFR: 98
Systolic BP: 121
Within data: yes

Drag the marker, or focus the map and use the arrow keys. Hold Shift for larger steps.

Hazard relative to the reference, by contour band.

Cox model with restricted cubic splines and an eGFR × SBP interaction (likelihood-ratio p = 3×10⁻⁵), adjusted for age and sex. NHANES 1999–2018, 46,469 adults, 6,688 deaths. Hazards are associations: the shift button reads the surface at a new position and is not a trial estimate of what treatment would do. The age path joins population medians by age band (NHANES 2017–18), which is cross-sectional and does not follow one person.

What to notice

The ground rises steeply as kidney function falls below about 60. Raised blood pressure costs little when kidneys are strong, and much more when they are not. That interaction is invisible on a report that lists the two values in separate rows.

The median adult walks uphill with age, from eGFR 110 and SBP 115 in their twenties and thirties to eGFR 76 and SBP 132 after 60.

The full research instrument

All 238 biomarkers, their sources, population distributions, cohort validation and trajectories are in the open research dashboard.

Open the research dashboard