PFLPhysiological Fitness Landscape

Collaborate

Whether PFL works is an empirical question. We are assembling the people to answer it.

Mathematicians and statisticians

Stochastic processes, joint longitudinal–survival models, identifiability, information theory. The open problems are listed under Mathematics.

Cohort and data holders

Repeated blood measurements on the same people with linked outcomes. Analyses run under your data agreements, and only aggregates are shared.

Health systems

Dense routine labs and the clinical questions they could answer. A retrospective validation is the first step.

Funders

A staged programme with explicit go and no-go points, each tied to a preregistered test.

Clinicians and beta testers

Help shape the position report, and test whether it changes decisions.

Open-source contributors

Code, curation of hazard curves and evidence grading. Everything is public.

Write to mhalma@opensourcemed.info

Open by default

Code, curves, sources and aggregate results are public. Analyses are preregistered before outcomes are examined.

Source code · Preregistration · Research dashboard