PFLPhysiological Fitness Landscape

Physiological Fitness Landscape

Medicine measures where you are. PFL measures where you are heading.

Every biomarker carries a mortality risk that changes continuously, not at a cut-off. Put those curves together and health becomes a landscape: a position, a direction of travel, and a set of moves that change the route.

  1. Where you areYour position on every hazard curve at once.
  2. How you got thereThe trajectory behind today's values.
  3. Where you are headingDrift with age, and how fast.
  4. Whether it can changeWhich moves lower the ground beneath you.
Mortality hazard1.00× reference
eGFR
98
Systolic BP
121

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Hazard relative to the reference, by contour band.
All-cause mortality hazard across kidney function (eGFR) and systolic blood pressure, relative to eGFR 98 and SBP 121. Fitted on 46,469 US adults with 6,688 deaths (NHANES 1999–2018, linked mortality to 2019). The dashed path shows the median adult at ages 20–39, 40–59 and 60+. The shaded edge marks combinations too rare to estimate.
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